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Patients should contact their healthcare provider if they experience persistent or severe dehydration symptoms, orthostatic dizziness, inability to keep fluids down, or very low urine output

They are now commonly used when: Metformin alone is no longer enough Weight gain is contributing to worsening glucose control There is a need to minimise hypoglycaemia risk Someone has existing cardiovascular disease or multiple risk factors For many people, GLP-1 therapy can delay or reduce the need for insulin, or allow insulin doses to be kept lower and safer

These skin-brightening injections can correct any dark spots or discolouration on the skin

Prescribing is concentrated in older teens, girls, and those with more severe obesity: for example, adolescents with class 2 or 3 obesity had 413 times higher prescription rates than those with milder obesity