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While the level of evidence for each compound varies, all of them lack the kind of large, well-controlled trials in humans that are necessary to establish safety and effectiveness, which is required for drug approvals
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Acknowledgements Thanks to the Taikang Health Investment Youth Medical Research Start-up Fund (2022018) for supporting this research
2003, doi: 10.1016/S0015-0282(02)04948-8
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