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The MT1 and MT2 receptor heterodimer is associated with G q , which enables the production of protein kinase C (PKC) and the increase of calcium associated with IP 3 (60, 77, 80, 81)
And no studies personalised interventions to pathophysiological sub-groups, such as mitochondrial dysfunction or oxidative stress, or examined biological characteristics of treatment responders, which would be informative
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