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[Science] Melideo, SL

Clinical studies on neuroprotection of GLP-1RAs After numerous preclinical studies have examined the neuroprotective effects of GLP-1RAs, new clinical trials have been initiated

For instance, curcumin has been shown to reduce amyloid plaque burden more effectively in APOE3 than in APOE4 transgenic mouse models (Far et al., 2024)

When cytoplasmic concentrations of neurotransmitters rise dangerously high, TAAR1 activates G-protein-dependent signaling pathways that recruit intracellular kinases, including protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaMKII) (Underhill et al., 2020)