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Some things to know: If you have a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2, semaglutide and tirzepatide may not be right for you

Understanding the differences in the mechanism of action and potential side effects between the two medications is crucial for a smooth transition

Consultation with an endocrinologist or obesity medicine specialist is appropriate when first-line management with tirzepatide does not produce expected results

Additional methodological details, including model specification and sensitivity analyses, are provided in the supplementary material