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Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure

A multidisciplinary expert consensus published in 2022 suggested pausing or reducing the dose of metformin therapy during initiation of a GLP-1 RA as an option to reduce GI side effects (Gorgojo-Martnez et al, 2022), although this is not widely practised in the UK

BMI did not differ between males and females, thus not explaining the observed differences between genders (Supplementary figure 2t)

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