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Npj Digit
The phosphocholine head group in phospholipids of normal healthy cell membranes is not accessible but, when cells are damaged and die, enhanced availability of lysophosphatidylcholine and disruption of the lipid bilayer expose phosphocholine residues to which CRP avidly binds ( In acute respiratory distress syndrome (ARDS), there is extensive overproduction of free radicals and reduced extracellular and intracellular GSH leading to oxidative cell damage ( Glutathione is an important antioxidant in the lungs, but its concentration is low in the airways of patients with cystic fibrosis, since GSH is transported into the airways by the cystic fibrosis transmembrane conductance regulator, which is mutated in cystic fibrosis patients (123), and then, the use of precursors of GSH synthesis like NAC and cystine could be more effective in the synthesis of GSH (124)
The 2007 trial included 412 participants
Compared with healthy circulating neutrophils, those from patients with RA displayed a higher production of reactive oxygen species (ROS), as well as a higher expression of Fc receptors [8, 9]
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