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Another approach, which seems promising for future treatment of NAFLD, is the combination of GLP-1 and glucagon, since the latter may potentiate incretin-mediated weight loss and increase lipid utilization and FFA oxidation in the liver
We also evaluated whether GLP-1R and PKA signalling were involved in the protective effect of metformin in HUVECs
However, in sub-healthy conditions such as SCD, there is significant retention of mitochondria, large amounts of heme iron and molecular oxygen in red blood cells, which are therefore susceptible to ferroptosis stress
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