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GLP-1s are usually not recommended for people who: Have severe gastrointestinal issues, such as gastroparesis Have an intolerance or allergy to GLP-1s Are pregnant or breastfeeding Have a personal or family history of rare forms of thyroid cancer called medullary thyroid cancer or multiple endocrine neoplasia type 2 Behavioral health is an important consideration before starting GLP-1 medications

Tirzepatide: How They Work Although glucagon-like peptide 1 drugs (GLP-1s) may seem relatively new, theyve been around for over 15 years, with volumes of data to support their efficacy

Injecting into lipohypertrophic tissue reduces drug absorption, creating unpredictable pharmacokinetics that undermine the very stability microdosing aims to achieve

5.6% reported using them for 12 months