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3.1.2 Relationship between lipid metabolism and ferroptosis PUFAs, particularly those containing bis-allylic hydrogen atoms such as arachidonate (AA) and adrenate (AdA), are highly susceptible to oxidation by ROS, making them central to ferroptosis (81)
Both Danuglipron and Lotiglipron ultimately failed due to liver-related concerns, despite strong oral bioavailability and early promise
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