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Metabolites generated in the gut from various microbial metabolic processes alter host-specific responses
Z-Asp(O t Bu)-His(Boc)-D-Phe-Arg(HCl)-Trp-Lys( Boc)-NH 2 ( 10 ) The crude product 9 (32 g, 30.69 mmol), obtained from the previous step, was dissolved in methanol (600 mL), then Pd(OH) 2 (1 g) was added and the mixture was hydrogenated with hydrogen while stirred at r.t
The 12mg dose delivered the largest HbA1c reduction (up to 1.6 percentage points) against a 0.2-point placebo response
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