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Five of these trials have shown superiority in reducing MACE compared to placebo, while all have confirmed the cardiovascular safety of GLP-1 RAs ( 4.3.1 Cardiovascular outcomes in GLP-1 RAs studies The ELIXA trial, which included 6068 patients, was the first to investigate the cardiovascular effects of GLP-1 RAs
Utilization patterns of glucagon-like peptide-1 receptor agonists in patients with type 2 diabetes mellitus in Germany: a retrospective cohort study
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This shortens the titration period but introduces greater side effect risk
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