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In between-drug comparisons, tirzepatide at doses of 15 mg, 10 mg and 5 mg demonstrated greater efficacy than semaglutide at doses of 2.0 mg (MD = 4.60 kg [95% CI 7.94, 1.26]), 1.0 mg (MD = 3.53 kg [95% CI 4.80, 2.25]) and 0.5 mg (MD = 2.75 kg [95% CI 4.23, 1.28]), respectively (ESM Table 11)

A small breakfast at 7 AM, a snack at 10 AM, lunch at 1 PM, another snack at 4 PM, and dinner at 7 PM works better than big meals at 8 AM, noon, and 6 PM

Researchers select format based on route of administration requirements and whether the protocol calls for fixed or variable dosing across experimental arms

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