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Preclinical studies demonstrate that DSIP can alter pain threshold responses, with observed effects that are not reversed by opioid receptor antagonists such as naloxone, suggesting involvement of non-opioid or indirect neuromodulatory pathways [7]

Patients should also be alert to changes in the pen's mechanical function, such as difficulty advancing the dose selector or resistance during injection

Hair loss during GLP-1 therapy typically begins 8 to 12 weeks after treatment starts, peaking around 4 to 6 months, then improving as the body adjusts and weight stabilizes

Side effects like nausea and vomiting are common