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Superoxide radicals (O 2 ), a type of ROS generated during metabolic processes, are converted into H 2 O 2 and O 2 by SOD, using metal as a cofactor (187)

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However, only about a half of newly generated cells survive in the long term to integrate in the preexisting neural network, and a subgroup of these neurons will show abnormal morpho-functional development, including aberrant migration, bipolar morphology, or an abnormal functional development

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