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Notwithstanding, previous studies have documented beneficial effects of the activation of estrogen receptors in diet-induced obese females, by reducing body weight and fat accumulation and improving leptin resistance at central level 53,54

a , Representative images of CD68 IHC staining of mouse liver and the ( b ) pathologist graded scoring

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Liu YL, Ford HE, Druce MR et al (2010) Subcutaneous oxyntomodulin analogue administration reduces body weight in lean and obese rodents