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Most nausea, vomiting, and GI discomfort peak in weeks 24 and resolve by week 812 as your body adapts
Previous studies in obese rodents and diet-induced obesity models have shown that GEs primary site of action is central, particularly within hypothalamic regions such as the supramammillary nucleus, lateral hypothalamus, and the nucleus of the solitary tract (Tiano et al., 2015)
This effect is minimal over 2-3 weeks but can become relevant for vials kept for longer periods
It has been also observed that up to 30% of dietary AGEs were absorbed in human organism, two-thirds of the absorbed AGEs remained in the body and one-third was excreted during the next 3 days (7577)
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