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Source: Frontiers in Physiology Source: Endocrine Reviews Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. A wide range of seemingly unrelated disorders have underlying pathophysiological mechanisms in common, namely reactive oxygen species (ROS) production, the accumulation of mitochondrial DNA (mtDNA) damage, resulting in mitochondrial dysfunction: Schizophrenia Bipolar disease Dementia Alzheimers disease Epilepsy Migraine headaches Strokes Neuropathic pain Parkinsons disease Ataxia Transient ischemic attack Cardiomyopathy Coronary artery disease Chronic fatigue syndrome Fibromyalgia Retinitis pigmentosa Diabetes Hepatitis C Primary biliary cirrhosis More How Mitochondria May Affect Cognitive Function When someone has cognitive impairment , their ability to think, learn, remember, use judgment, and make decisions is affected, often by an underlying condition

Required for 500+ enzymatic reactions, NAD+ fuels cellular energy, DNA repair, and sirtuin activation