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While there is no evidence of common structural or functional brain alterations in PAIS, probably due to its heterogeneous origin and lack of conceptualization, ME/CFS has been extensively studied with MRI (magnetic resonance imaging), as recently reviewed by Nelson et al
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Folinic Acid Can Cross the Blood-Brain Barrier Unlike folic acid (which must be converted to 5-MTHF and is poorly transported when FR is blocked), folinic acid (5-formyl-THF) can be directly converted to 5-MTHF
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