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It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC

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10.1093/humrep/deaa366 51 TollH.BergerP.HofmannA.HildebrandtA.OberacherH.LenhofH

Eye-level view of laboratory equipment used to study GHK-Cu absorption and stability Summary GHK-Cu shows promise for skin and health benefits, but its oral bioavailability is limited by digestive breakdown