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As with any injectable therapy, avoid use if the solution is cloudy, discolored, or contains particulates, or if the ampoule/vial integrity is compromised
If the powder does not fully dissolve in the first two to three minutes of swirling, stop and let the vial rest for one to two minutes, then swirl again
The faster damaged tissue can stabilize, the less mechanical disruption occurs during the vulnerable early healing phase
Then there is the amplification of the trend by the media
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