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(3) insufficient sample size in some subgroups (e.g., 54 cases in the 360 days

Strengths and limitations The primary strength of this review lies in its multidimensional framework, integrating high-quality randomized controlled trials, real-world evidence, regulatory documents, and expert consensus to support a phenotype- and complication-oriented treatment strategy for obesity

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196 For people who are unable to attain weight-related health improvements with behaviour modifications and pharmacotherapy, or unable to sustain weight loss after treatment discontinuation, referral to specialised care is generally required