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Shared decision-making between clinician and patient is essential when choosing between these agents
This randomized, controlled trial compared the effects of L-citrulline (6g) , combined L-citrulline (2g) + glutathione (200mg) , and placebo over 4 weeks
The most common adverse effects are mild gastrointestinal symptoms (nausea, vomiting, diarrhea) that typically occur at rates similar to placebo in controlled trials
The enlarged Tregs oppose the function of antigen-presenting cells (APCs), obstruct the activation of T cells, and reduce the anticancer capabilities of effector T cells (Teff) during the course of tumor development [76]
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