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Glutathione is the "master antioxidant" because it is found in practically every cell in the body

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It is found in almost every single cell and is involved in multiple processes, even though it is most well-known for its role in detoxification and its ability to neutralize free radicals

They likely reflect the difference between pathological IGF-1 excess (which does appear to increase cancer risk and accelerate ageing in some models) and normalisation of IGF-1 in individuals whose levels have declined below an optimal physiological range due to somatopause