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GHKs histidine residue provides nitrogen coordination sites that stabilize Cu in a square planar geometry, creating a complex with a dissociation constant (Kd) around 10 Mamong the highest copper-binding affinities of any naturally occurring peptide
Ethics declarations Competing interests D.H.R has received personal remuneration from services as a scientific advisor to Abbvie, Altimmune, Amgen, AstraZeneca, Boehringer Ingelheim, Biohaven, Calibrate, Carmot/Roche, CINRx, Currax, Epitomee, Fractyl, Gila, Lilly, Nestle, Novo Nordisk, Pfizer, Regeneron, Scientific Intake, Source Bio, Structure Therapeutics, Wondr Health, and Zealand, She serves on Speakers Bureau for Novo Nordisk and Lilly