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Key pathways such as PI3K/AKT/mTOR (PAM), RAS/RAF/MEK/ERK [22], and Notch are frequently activated in GBM, promoting cell proliferation, survival, and invasion, while also contributing to the resistance of GBM cells to chemotherapy and radiation therapy

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The medial region, called the isthmus, is flanked by wing-shaped left and right lobes

Obesity represents a major contributor to residual risk that traditional cardiovascular medications dont address