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For example, in colon cancer cells (PC-3 cell line), at curcumin concentrations ranging from 0 to 50 M, treatment was associated with decreased phosphorylation of Akt kinase (Akt), mammalian target of rapamycin (mTOR), glycogen synthase kinase (GSK3), Forkhead box protein O1 (FOXO1), and other proteins (Yu et al., 2008)
Identity confirmed by mass spectrometry
413 Partial ablation of astrocytes in the prefrontal cortex of healthy rats (by injection of gliotoxin L--aminoadipic acid) resulted in the development of depressive-like behaviours, whereas injection of neurotoxin ibotenate did not have such an effect
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