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Of significance is the fact that the thiazolidinedione (TZD) class of drugs used to treat the hyperglycemia of type 2 diabetes (see the next section) activate PPAR which in turn increases the level of activity of PGC-1
According to the Food and Drug Administration (FDA), animal studies suggest it can cause birth defects and an increased risk of pregnancy loss
The bottom line The cleanest fair summary of TRIUMPH-1 today is: retatrutide just produced 28.3% mean weight loss at 80 weeks 45.3% of participants on 12 mg reached 30% or greater weight loss 65.3% fell below the BMI 30 obesity threshold and 37.5% of those starting with class 3 obesity also got below that threshold 1 That is a major obesity-drug milestone
On the other hand, acceptance will be limited because of the stringent guidelines that prevail in Japan for prescription drug use
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