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In the Phase 3 TRIUMPH-4 trial, participants on the 12 mg dose lost an average of 28.7% of their body weight about 71 pounds over 68 weeks
Cellular Thermal Shift Assay (CETSA) HEK293T cells cultured in 100 mm 20 mm tissue culture dishes were treated with media containing DMSO or GPX4 activator for 3 h at 37C in a tissue culture incubator (with 5% CO 2 )
According to The STEP 1 trial, published in the New England Journal of Medicine in 2021, the length of the treatment was 68 weeks with the following results
It is FDA approved for weight management and to reduce the risk of stroke, heart attack, or other cardiovascular death in people who are overweight or have obesity
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