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Skeletal metabolism: Long-term administration in animal models has been associated with an increase in bone mineral content, suggesting that elevated GH levels may support bone homeostasis and tissue remodeling

A2ARi treatment also upregulated gene levels of other antioxidant enzymes, txnrd1 , prdx1 , prdx3 , and park7 (Supplemental Figure 8E), though their expression levels were lower than that of gpx4 (Supplemental Figure 8F)

It is a synthetic version of a fragment of the natural epithalamine peptide, originally isolated from bovine pineal gland extracts in the 1980s

Supplementary Data (download XLSX Source data for Supplementary Fig