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The effects of S and Sirts on the microglial inflammasome has been reviewed elsewhere (Figure 4

Therefore, a tri-agonist was designed, incorporating residues from GLP-1, glucagon and GIP, as well as having a stabilising CEX

Sikiric, P., Seiwerth, S., Grabarevic, Z., Petek, M., Rucman, R., Turkovic, B.,