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Studies suggest that up to 25 to 40% of the weight lost during GLP-1 therapy may come from lean mass, primarily skeletal muscle, if active steps are not taken to preserve it [23]
While this mechanism primarily targets fat burning, it can also affect muscle protein synthesis, potentially leading to some muscle loss
Sex: People born female at birth tend to respond better to semaglutide than people born male at birth
IBS patients need to avoid long periods of not eating (to prevent bile acid buildup or hunger-triggered motility which can cause pain), so managing GLP-1 nausea is important
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