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Based on this assessment, a healthcare provider can recommend the appropriate form and dosage of B12 supplementation
This flexibility allows for personalized treatment approaches but increases complexity
Lidocaine is extensively metabolized in the liver, so drugs that decrease hepatic blood flow (e.g., propranolol) or inhibit CYP1A2/CYP3A4 (e.g., fluvoxamine, ketoconazole, clarithromycin) may elevate systemic concentrations and increase the risk of central nervous system or cardiovascular toxicity
Intranasal administration leverages the highly vascularised nasal mucosa for systemic absorption
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