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Using electronic health records from the Apollo dataset, investigators identified approximately 66 million patients with new prescriptions for semaglutide or metformin between January 2016 and December 2023

Abbreviations: Fmoc: 9-fluorenylmethoxycarbonyl Boc: Tert-butoxycarbonyl DCM: dichloromethane DMF: N, N-dimethyl form amide DIC: N, N -diisopropyl carbodiimide DIE A: Diisopropylethylamine HOBt: N-hydroxy benzotriazole CTC resin: 2-Chlorotrityl chloride resin SPPS: Solid phase peptide synthesis TFA: Trifluoroacetic acid TIPS: Triisopropyl silane EDC.HC1: 1 -(dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride DTT: Dithiothreitol EDT: 1 ,2-Ethanedithiol Detailed Description of the Invention The present invention provides an improved process for the preparation of Semaglutide by making appropriate fragments on solid support, followed by condensing these fragments using solution phase approach with higher yields and purity

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