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6 Dulaglutide (Trulicity): Mainly marketed as Trulicity in the US, dulaglutide has had FDA approval for type 2 diabetes management since 2014
A combined analysis of four clinical trials including both people with and without AD did not report any effect of GLP-1RAs on cognitive outcomes.26 Most recently, an umbrella review covering a selected portion of the available literature has argued that GLP-1RAs may be beneficial in dementia.73 All these combined analyses have several methodological issues (including unclear study selection process and inadequate assessment of clinical and methodological heterogeneity of included studies), preventing any robust recommendation to be made on the use of GLP-1RAs in dementia
GHK-Cu is 340.4 Da, which sounds permissive, but the practical absorption rate of charged tripeptides through the stratum corneum is essentially zero without enhancement 4
psychiatry 29 (2), 269286
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