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Although patients on semaglutide, the drug in Ozempic and Wegovy, lost on average 10 percent of their body weight, a third lost less than 5 percent in one clinical trial

In a phase 2 study, patients with obesity on the highest dose (12 mg) lost an average of about 24% of their body weight in 48 weeks

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When cellular stress surpasses a reversible threshold, mitochondria-nucleus interactions push cells toward irreversible fates: m decreases, accompanied by ROS overproduction and ATP depletion, while BAX/BAK-mediated MOMP triggers apoptosis [265]
