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Medication given this way is absorbed more slowly than if injected into a vein or taken by mouth (orally), sometimes over a period of 24 hours

In this regard, we speculate that the irrelevance of this study may stem from the method of Se measurement, which is available in whole blood, serum (79, 80), urine (81), nails (82), and questionnaires (83)

Some researchers posit that this effect occurs via an intrinsic mechanism, while others hypothesize that it may be mediated through the paracrine actions of insulin or somatostatin

Notably, there were no hepatic decompensations or increased side effects in the semaglutide group, suggesting that GLP-1 agonists are likely safe in compensated cirrhosis