constipation while on semaglutide and constipation: the straight facts Constipation on Semaglutide: Relief Strategies

What Clinical Trials Show In large obesity trials: Average weight loss is ~15% of starting body weight with semaglutide 2.4 mg Average weight loss is ~2022% of starting body weight with tirzepatide 15 mg The majority of weight loss occurs within the first year of treatment Plateaus are common after significant weight reduction Some people lose more, some less but a flattening of the weight-loss curve is expected , especially after meaningful progress has already occurred

If gastrointestinal symptoms are interfering with daily life, your prescriber might pause or slow your dose escalation schedule

Both pharmacological and non-pharmacological strategies may be employed, guided by the severity and nature of symptoms

Nausea is more common, particularly in the first 24 to 48 hours after injection