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Under physiological conditions, ROS plays a vital role in maintaining cellular homeostasis by regulating the endogenous antioxidant pool ( 2 O 2 production ( Excessive ROS accumulation is an important factor in the pathogenesis of different diseases
Its main hormonal actions are illustrated in Fig
Smith 2010
The established urinary threshold level of 150 g/mL may be reached (rarely, but possibly) in some individuals within 6-20 hours of taking some long-acting therapeutic formulations
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