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Since nanotechnology still needs systematic clinical trials before clinical use and cannot be substituted for traditional animal experiments, more ethical and regulatory discussions and norms are required before ensuring their safe, effective, and legal application in the treatment

Antioxidants, such as N-acetylcysteine (NAC) and glutathione, have been examined regarding their potential protective effects against ROS-induced ototoxicity (Noack et al

For example, the improvements in cardiovascular outcome have been evidenced in a number of large-scale randomized controlled clinical trials on cardiovascular disease (102)