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In people without pernicious anemia, about 0.5 g/day of B12 is reabsorbed by enterohepatic circulation in which B12-containing bile is secreted by the liver into the digestive tract where the B12 is then reabsorbed via intrinsic factor
At higher temperatures, its vapor pressure increases, meaning more of it will exist as a gas in the headspace of the vial rather than dissolved in the water where it needs to be to inhibit bacterial growth
Even without a deficiency, they provide the structure and processes necessary throughout every stage of life
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