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Similarly, in the study of triple negative breast cancer (TNBC) development, the actin fiber-associated protein 1-antisense RNA1 (AFAP1-AS1) was identified as targeting miR-145 to regulate MTH1 expression, thereby promoting proliferation and invasion

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Final research-target dose 2.4 mg + 2.4 mg weekly Titration length ~16 weeks Trial duration 68 weeks (REDEFINE 1 / REDEFINE 2) Route Subcutaneous, once weekly Compound Delivery: 2.4 mg / 2.4 mg Maintenance Pre-blended vials simplify weekly administration to a single injection but lock the ratio at 1:1

Lactoferrin-conjugated superparamagnetic iron oxide nanoparticles as a specific MRI contrast agent for detection of brain glioma in vivo