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Overall, our results involving alterations in glutamatergic signaling in DAT-males suggest a downregulation of both pre- and postsynaptic processes, which could correlate with age-related deficits in cognitive and behavioral responses (Castillo-Vazquez et al., 2024), and were not as prominent in DAT-females (GSE295369)
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227 Preclinical research has shown quercetin reduces expression of adhesion molecules on endothelial cells and platelets, lowers oxidative stress, inhibits LDL oxidation, supports nitric oxide production and healthy blood vessel function, improves glucose metabolism, and reduces inflammatory marker levels
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