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Folate matters here too, since homocysteine also rises when folate is low, which is why a folate blood test is often run alongside
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You can stay at the lower dose longer if you need time to adjust
Dos Santos Mello M, Ribas GS, Wayhs CA, Hammerschmidt T, Guerreiro GB, Favenzani JL, Sitta , de Moura Coelho D, Wajner M, Vargas CR (2015) Increased oxidative stress in patients with 3-hydroxy-3-methylglutaric aciduria
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