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These data point to a previously unrecognized effect of KG-mediated epigenetic rewiring through histone acetylation
The SURPASS clinical trial program, which evaluated tirzepatide in over 10,000 patients with type 2 diabetes, did not identify palpitations as a significant safety signal
Furthermore, it has emerged that supporting or inducing mitochondrial bioenergetics, stress responses, mitophagy, and other adaptation mechanisms is critical to mediate some of the health or longevity benefits observed in studies using NAD + modulation strategies
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