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Despite initial pharmaceutical interest, AOD 9604 did not progress through the full clinical trial pathway required for regulatory approval, and it holds no Marketing Authorisation (MA) from the MHRA or EMA

For instance, investigations into defective immunometabolism in CF macrophages have utilized the Seahorse Extracellular Flux analyzer, revealing impaired oxygen consumption, both at baseline and following infection with challenging pathogens like Burkholderia cenocepacia (Hamilton et al., 2021)

Given the short timeframe of the GLP-1 demonstration, it is unlikely that there will be cost offsets from improved health due to increased GLP-1 use for obesity that can be documented

It not only supports individuals with type 2 diabetes but also serves as a powerful aid in weight management when combined with a healthy lifestyle