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Elegant studies of this type have been done for example by Leshan and colleagues to show that only a subpopulation of VTA dopamine neurons projecting specifically to the amygdala but not the NAc is activated by leptin (Leshan et al., 2010)
Smaller, more frequent meals, avoiding high-fat foods during the adjustment period, and maintaining hydration all help manage GI discomfort
During your first month, you may see weight reduction ranging from 3 to 8 pounds, depending on your individual physiology, starting dose, and lifestyle factors
Lancet 403 (10437), 16351648 (2024)
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