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Day and colleagues were the first group to use a series of modifications to the C-terminal portion of the glucagon sequence to increase GLP-1R potency, combined with PEGylation to generate two PEGylated peptides with adequate co-agonist properties, one unbalanced towards GLP-1R, and the other a near-balanced agonist at both GLP-1R and GCGR
Additionally, research used to back BMI leaves much to be desired (more on this later)
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Patients should always consult their GP or specialist before considering any unlicensed treatment, and should only receive retatrutide within the context of a regulated clinical trial or under appropriate medical supervision
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