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A cooperative role of NRF2 and C/EBP (a transcription factor of the CCAAT/enhancer binding protein family) was described in generating tumor-specific enhancers that promote tumor initiation via NOTCH3 activation (Okazaki et al, 2020)

It can actually be brought on by high OR low stomach acid (both conditions can create the symptoms, which can be confusing), but with my patients at the telehealth functional medicine center I see low stomach acid way more often, and often among those who thought they had the opposite problem

Interestingly, this NMDA receptor-mediated activity-dependent myelination requires the simultaneous presence of glutamate and growth factors like brain derived neurotrophic factor (BDNF), hinting at the importance of surrounding glial cells (Lundgaard et al., 2013)

It also depends on any swallowing or digestion problems