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By utilizing biocompatible and highly hydrophilic modifying groups, such as polyethylene glycol (PEG), hyaluronic acid (HA), and polyamine compounds (like polyethyleneimine, PEI), nanoparticles can increase the binding ability with glycoproteins on the bladder mucosal surface, prolonging the drug retention time in the bladder and reducing drug loss due to urine flushing

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Liu Y, Yu Z, Zhao S, Cheng L, Man Y, Gao X, et al

You want to inject right in that tent so the needle will be going into an air pocket between the skin and the muscle